Three National highways – N2, N10, and N11 – and a few Regional highways such as the R113, R114, R116 and R181, serve the region.
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The national capital of Accra is also connected to the region by the N2 which terminates in Kulungugu in the Upper East Region.
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The N10 originates from Yemoransa in the Central Region and connects through Kumasi in the Ashanti Region and terminates at Paga in the Upper East Region.
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