He was a member of 1970s punk band The Plugz (which became a popular roots band in the 1980s), Cruzados, Havalinas, Izzy Stradlin & the Ju Ju Hounds, and has toured and/or recorded with Joan Osborne, John Doe, Cracker, Bob Dylan, Jimmy and the Mustangs, 47C and many others.
Miles was born to Frank and Marie Marsico and is the nephew of former bassist of the Cruzados, Tony Marsico.