Piseth Pilika was born to Oak Harl and Meng Mony in Phnom Penh.
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In October 1999, following Pisith Pilika's assassination, the French magazine L’Express claimed that the actress’ diary recounted a love affair with Cambodian Prime Minister Hun Sen, and pointed to Bun Rany, Hun Sen's wife, as responsible for arranging the shooting.
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The magazine also claimed that on her deathbed the actress had named Bun Rany to several people.