William Donald Kelley (1925–2005), orthodontist and inventor of alternative cancer treatments
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William D. Kelley (1814–1890), U.S. Representative from Pennsylvania
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William Melvin Kelley, novelist and professor at Sarah Lawrence College, 2008 winner of the Anisfield-Wolf Book Award for lifetime achievement
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William K. Kelley, Deputy White House Counsel for the George W. Bush administration
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