Modifications to this flux that may improve ethanol production include deleting the GND1 gene, or the ZWF1 gene.
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This can be accomplished either by native xylose fermenting yeasts such as Scheffersomyces Pichia stipitis or by metabolically engineered strains of Saccharomyces cerevisiae.
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In attempts to generate S. cerevisiae strains that are able to ferment D-xylose the XYL1 and XYL2 genes of P. stipitis coding for the D-xylose reductase (XR) and xylitol dehydrogenase (XDH), respectively were introduced in S. cerevisiae by means of genetic engineering.
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Pichia stipitis is not as ethanol tolerant as the traditional ethanol producing yeast Saccharomyces cerevisiae.
metabolism | Metabolism | Inborn error of metabolism | Human iron metabolism | D-xylose reductase | Carbohydrate metabolism | carbohydrate metabolism |