Isaac became a foundryman in Bristol with involvement in the south Wales Dowlais Ironworks and Cyfarthfa Ironworks, and starting the Plymouth Ironworks with John Guest.
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By now, Isaac was living in Cartmel, enjoying several business interests, including the Lowwood iron company.
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Some time between 1721 and 1723, Wilkinson moved to Workington where he worked at the Little Clifton furnace which probably produced cast iron by smelting with coke.
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He seems to have received some basic education before being apprenticed a foundryman, probably at the nearby Swalwell works.
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